North American Pharmacist Licensure Examination

Here you have the best Test Prep NAPLEX practice exam questions

  • You have 154 total questions across 31 pages (5 per page)
  • These questions were last updated on February 6, 2026
  • This site is not affiliated with or endorsed by Test Prep.
Question 1 of 154
Which of the following represents the major route of metabolism for acetaminophen?
Suggested Answer: A

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Question 2 of 154
A 15-year-old presents with 6 days of nasal congestion with thin, clear rhinorrhea. She notes mild facial pain but has had no fevers. She feels her symptoms are improving.
What is the most likely cause of her symptoms?
Suggested Answer: B

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Question 3 of 154
A 72-year-old woman suffers from a major depressive episode. She has a history of coronary artery disease, atrial fibrillation on anticoagulation therapy, sick sinus syndrome, glaucoma, and chronic obstructive pulmonary disease.
Which of the following medications is most appropriate for the treatment of her depression?
Suggested Answer: E

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Question 4 of 154
A 20-year-old student came to the emergency department with primary complaints of palpitations, low-grade fever, and anxiety for 2 months. She reports that she is irritable and suffers severe mood swings that is interfering with her sleep and relationships (she admits to crying spells and frequent fights with friends and family). She has also lost 12 pounds in the past 2 months with no apparent alteration in her diet or physical activity (though she is happy with her weight loss). She denies any past medical problems, though her friends have always been worried that she eats too little.
Her temperature is 38.0 C (100.4 F), blood pressure is 148/62 mm Hg, pulse is 122/min and regular, and respiratory rate is 28/min. Examination reveals a bruit heard over the anterior neck, fine tremor of the hands, and warm, moist skin. Her eyes and eyelids do not move together during finger following test (with steady head). Laboratory work is sent, including a thyroid panel, but will not be available until tomorrow morning.
Which of the following is the most appropriate initial management at this time?
Suggested Answer: D

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Question 5 of 154
What is the best anti-thyroid regimen in a pregnant woman who has clinically significant hyperthyroidism?
Suggested Answer: D

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About the Test Prep NAPLEX Certification Exam

About the Exam

The Test Prep NAPLEX (North American Pharmacist Licensure Examination) validates your knowledge and skills. Passing demonstrates proficiency and can boost your career prospects in the field.

How to Prepare

Work through all 154 practice questions across 31 pages. Focus on understanding the reasoning behind each answer rather than memorizing responses to be ready for any variation on the real exam.

Why Practice Exams?

Practice exams help you familiarize yourself with the question format, manage your time, and reduce anxiety on the test day. Our NAPLEX questions are regularly updated to reflect the latest exam objectives.