Correct Answer: CNFS on vSAN is the best solution for hosting user profile shares in a highly available manner while remaining guest OS independent. NFS (Network File System) on vSAN allows for the creation of file shares that can be accessed by different operating systems including Windows, Linux, and macOS. This aligns with the requirement of being guest OS independent and provides the necessary high availability for user profiles. iSCSI, on the other hand, is typically used for block storage and would not be the optimal choice for file shares.