Seeding the MSDP (Media Server Deduplication Pool) is particularly beneficial in scenarios where there is a significant amount of data to be backed up or replicated over long distances or to new locations. New client backups over WAN benefit from seeding because it reduces the amount of data sent across the network, improving backup performance and reducing bandwidth usage. Similarly, new replication to a new DR (Disaster Recovery) site benefits from seeding as it ensures that initial replication is more efficient by transferring only unique data chunks. Both scenarios address the challenges of large data transfers and network efficiency.