In this scenario, where the company needs to comply with new government regulations that impacted its strategy, the program manager should:
D. **Review resource capacity and capability, program priorities, and interdependencies, and create a change request to modify the program roadmap to ensure strategic alignment.**
This option involves a comprehensive approach. It starts with reviewing the program's resources, priorities, and interdependencies in the context of the new regulations. The creation of a change request to modify the program roadmap ensures that these changes are formally proposed, evaluated, and implemented in a controlled manner. This helps in realigning the program with the updated company strategy while adhering to the new regulations.