The four actions that can be configured in an Anti-Spyware profile to address command-and-control traffic from compromised hosts are Reset, Quarantine, Drop, and Alert. Reset is used to terminate the connection, Quarantine isolates the threat, Drop discards the traffic, and Alert generates a log entry for analysis. 'Allow' and 'Redirect' are not typical actions to handle such traffic because they would not mitigate the threat; 'Allow' would permit the traffic, and 'Redirect' is generally used for other security purposes like URL filtering.