To connect to and interact with an Autonomous Database (ADB) from Python, the most appropriate method is by using the Oracle Client and the cx_Oracle interface. cx_Oracle is a Python extension module that enables access to Oracle Database, allowing developers to execute SQL commands, retrieve data, and perform other database operations from Python scripts. SQL Developer is a graphical tool used primarily for database development and management, not for direct interaction from Python. The DBD-Oracle interface is used with Perl, and JDBC Driver is intended for use with Java applications.