The high number of table lock waits is most likely due to the use of the MyISAM storage engine. MyISAM uses table-level locking, which can lead to a high number of lock waits when there are frequent write operations occurring on the tables. This is indicated by the high 'Table_locks_waited' value in the provided output. In contrast, InnoDB uses row-level locking and is generally better at handling concurrent operations without causing a high number of lock waits.