To isolate iSCSI traffic effectively, the administrator should create a specific network in Prism Central dedicated to Volumes. This separates iSCSI traffic from other network traffic, ensuring it remains isolated and secure. Configuring network segmentation alone (Option A) or creating a new network interface on CVMs (Option B) may not fully achieve the required isolation. Configuring the Data Services IP on an isolated network (Option C) might help in some configurations, but the most direct approach to meet the specific requirement is to create a Volumes network in Prism Central.