Correct Answer: BTo set up an alert that is guaranteed to trigger as soon as the API implementation stops responding to API invocations, the best option is to configure a 'worker not responding' alert in Anypoint Runtime Manager. This solution provides immediate monitoring and alerting of the worker's status, ensuring timely detection of any unresponsiveness. Other options either require additional implementation effort, like external health checks, or may not be as reliable or immediate in detecting the issue.