A website designed for optimal use considers various factors to ensure accessibility and usability for a wide range of users. Among the given options, lack of computer skills is a factor that affects usability but is not directly related to disability. Age-related disease, color blindness, and dyslexia are all conditions that fall under disabilities and require specific design considerations to accommodate those users. Therefore, designing for users with varying levels of computer skills ensures the website is user-friendly for those who may not be proficient with technology, thus enhancing the overall user experience.