C. The use of Version 1 UUIDs as primary keys that increase monotonically.
When designing schemas for Cloud Spanner, it is important to consider how the choice of primary keys can impact performance, especially under heavy load. Cloud Spanner splits data among servers based on the primary key values, so if the keys are monotonically increasing, as is the case with Version 1 UUIDs, new inserts are constantly added to the end of the table. This can create hotspots, where a single node receives a disproportionate amount of read and write requests, leading to performance bottlenecks and preventing linear scaling.