D - https://docs.citrix.com/en-us/sdx/current-release/single-bundle-upgrade/upgrade-netscaler-instance.html
Last bullet point in this section:
Upgrade Citrix ADC VPX instances
You can use the Management Service to upgrade one or more of the VPX instances running on the appliance. Before upgrading an instance, make sure that you have uploaded the correct build to the SDX appliance.
Before you start upgrading any instance, ensure that you understand the licensing framework and types of licenses. A software edition upgrade (such as from a standard edition to the enterprise edition or from an enterprise edition to the platinum edition) might require new licenses. Also note the following:
To prevent any loss of configuration, save the configuration on each instance before you upgrade any instances.
You can also upgrade an individual instance from the Instances node. To do so, select the instance from the Instances node. In the details pane, select the instance, and then in the Actions drop down menu, click Upgrade.